The Harrisburg Regional Chamber was initially known as the Harrisburg Board of Trade and was founded in the late 1800s. In 1912, it was decided that the organization should be formally incorporated as a Chamber of Commerce and by 1913 that official designation was given to the organization. The interesting fact, however, is that though the name has changed, the concept and objectives have remained constant throughout this entire history.

Recognized as one of the largest, most dynamic organizations of its kind, the Harrisburg Regional Chamber has combined a unique blend of business, community, and economic development services under one roof to improve the region's economic vitality and quality of life.